Resilience to Depression: The Promise of Psychological Vaccination

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Depression is a common and serious mental illness that affects millions of people worldwide. While there are effective treatments available, prevention is always better than cure.

A new study published in the journal Frontiers in Psychiatry suggests that a new approach called “psychological vaccination” could help to prevent depression. The study, by researchers from China and the United Kingdom, reviewed the evidence for resilience to depression and proposed a new model of psychological vaccination.

Resilience is the ability to cope with adversity and bounce back from difficult experiences. People who are resilient are less likely to develop depression, even when they experience stressful life events.

The study’s authors identified five key factors that contribute to resilience to depression:

  • Positive cognitive style: This includes having a strong sense of purpose in life, being hopeful, and having a positive outlook.
  • Positive emotion: This includes being able to experience and express positive emotions, such as happiness, joy, and gratitude.
  • Adaptive behavior: This includes being able to manage stress effectively, set realistic goals, and solve problems.
  • Strong social interaction: This includes having supportive relationships with family and friends.
  • Neural foundation: This includes having a healthy brain that is able to regulate emotions and cope with stress.

The study’s authors propose that psychological vaccination could be achieved by enhancing these five factors. This could be done through a variety of interventions, such as cognitive-behavioral therapy, mindfulness training, and social support groups.

The study’s findings suggest that psychological vaccination could be a promising new approach to preventing depression. More research is needed to confirm these findings and to develop effective psychological vaccination interventions.

In the meantime, there are a number of things that people can do to boost their resilience to depression. These include:

  • Practicing positive thinking: This involves focusing on the positive aspects of your life and developing a hopeful outlook.
  • Engaging in activities that you enjoy: This can help to boost your mood and reduce stress.
  • Building strong social connections: Having supportive relationships with family and friends can provide you with a sense of belonging and purpose.
  • Taking care of your physical health: This includes eating a healthy diet, getting enough sleep, and exercising regularly.

If you are concerned that you or someone you know may be at risk for depression, please seek professional help. There are effective treatments available that can help to improve your mood and quality of life.


Dai Q and Smith GD (2023) Resilience to depression: Implication for psychological vaccination. Front. Psychiatry 14:1071859. doi: 10.3389/fpsyt.2023.1071859