SSRI Doses and Effectiveness – High Dose vs Low Dose, Is There a Difference?

admin Best Practices, Major Depression, Treatments of Depression Leave a Comment

One of the questions that has bedevilled clinicians ever since the introduction of the first SSRI (Prozac, fluoxetine) is whether there is any relationship between SSRI doses and effectiveness. In other words, do higher doses result in greater effectiveness. I can recall about 20 years ago reading the first clinical trial looking at this question. It was an article published …

SSRI Dose Response

Peter Forster Major Depression, Treatments of Depression

It has long been unclear whether higher doses of SSRIs are associated with greater response. What has been clear is that higher doses are associated with significantly increased side effects. In fact previous research, whether individual studies or meta-analyses have failed to find a significant dose response with the result that many have felt that there is a flat dose response …