Prolon’s Fasting-Mimicking Diet Shows Promise in Reducing Biological Age and Disease Risk

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We have previously discussed Prolon, a modified fasting regimen created by a University of Southern California longevity study specialist. A scientific breakthrough study was disclosed and published on February 20, 2024 in Nature Communications, a highly respected scientific journal, suggesting that Prolon’s Fasting-Mimicking Diet (FMD) may hold significant potential in promoting longevity and reducing the risk of chronic diseases.

The key finding of the study is that following three cycles of Prolon’s FMD over three consecutive months (amounting to just 15 days) may lead to a median decrease in biological age score by approximately 2.5 years. This is a significant finding, as it suggests that the FMD may have the potential to slow down the aging process at a cellular level.

It’s important to note that this study was conducted in mice, and more research is needed to confirm these findings in humans. However, the results are promising and warrant further investigation.

The study also explored the potential long-term effects of incorporating FMD cycles into a lifestyle program. The simulations suggest that three cycles of FMD per year over 20 years may offer protection against various chronic diseases, including:

  • Diabetes
  • Cerebrovascular disease
  • Heart disease
  • Cancer
  • All-cause mortality

While these projections are encouraging, further research with human participants is crucial to confirm these potential benefits.

Based on these findings, Prolon recommends following the Prolon 5-Day FMD for three consecutive cycles when starting a healthy aging program. They also suggest incorporating three cycles per year for potentially maintaining long-term benefits.

Interestingly, the study highlights that the observed benefits appear to be independent of weight loss and primarily driven by cellular rejuvenation and metabolic reset. This is further supported by a recent human autophagy trial conducted by Prolon, which demonstrated a significant increase in autophagy (a cellular cleansing process) after just 3 days of the FMD, suggesting its potential for cellular rejuvenation.

Overall, this research provides exciting insights into the potential of Prolon’s FMD for promoting healthy aging and reducing the risk of chronic diseases. While further research is necessary, these findings offer a promising path forward for those seeking to optimize their health and longevity.


Brandhorst, S., Levine, M.E., Wei, M. et al. Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nat Commun 15, 1309 (2024).