Predicting Lithium Response with Functional Brain Imaging

Predicting Lithium Response with Brain Imaging

Peter Forster Bipolar Treatment, Testing Leave a Comment

Predicting lithium response with brain imaging may be an option in the future if the preliminary results of a study published in 2017 are confirmed. Researchers from the University of Cincinnati used three tools to create a program that was remarkably successful at predicting which bipolar patients would respond to lithium. 20 first onset bipolar patients who received adequate trials …

State and Trait Brain Function in Depression

State and Trait Brain Function in Depression

Peter Forster Basic Science, Major Depression, Psychobiology Leave a Comment

Understanding the neurobiology of depression involves more than just knowing about serotonin, we need to know how state and trait brain function in depression is different from brain functioning in those who have never had a major depression. State and trait are key concepts in understanding psychiatric conditions: state refers to those alterations in functioning that occur when someone is …

Brain Response to Stress in Depression

Brain Response to Stress in Depression

Peter Forster Basic Science, Major Depression, Psychobiology Leave a Comment

A study looking at the brain response to stress in depression offers important clues about changes in brain function that may be associated with vulnerability to depression and what happens when a vulnerable individual becomes depressed. Researchers looked at brain activity using functional MRI in three groups of people: people with untreated first episode major depression, people with a history …

Negative Self Appraisal and Brain Activity

Negative Self-Appraisal and Brain Activity

Peter Forster Basic Science, Major Depression, Psychobiology Leave a Comment

Negative Self-Appraisal and Brain Activity: Altered Function in Depression Within the Default Mode Network (DMN) are three structures that link negative self-appraisal and brain activity: The medial prefrontal cortex (MPFC) The posterior cingulate cortex (PCC) And the inferior parietal lobule (IPL) Negative self-appraisal refers to the relentless critical self talk that occurs in many people with depression. Many patients report …

Functional Brain Imaging in Depression

Peter Forster Basic Science, Best Practices, Major Depression, Psychobiology, Testing, Treatments of Depression

Is there a role for functional brain imaging in depression? Many people seeking treatment are interested in the notion that the brain imaging, particularly imaging that looks at neural activity, might be useful in guiding treatment. Up until the last couple of years the answer to this question has always been that the role is primarily restricted to research settings …

Functional Brain Imaging and Antidepressant Response

Peter Forster Basic Science, Testing, Treatments of Depression

One of the most exciting initiatives currently in the important area of  the treatment of depression is the International Study to Predict Optimized Treatment in Depression (iSPOT-D). This large multi-center initiative is based on a private industry and academic partnership that is designed to both identify best practices in the treatment of depression and also commercialize them. The most recent publication from this …