Qi Gong

admin General, Mental Health, Physical Conditions and Health, Psychobiology, Self Care Leave a Comment

Qi Gong is an ancient Chinese practice that combines physical postures, breathing exercises, and meditation. It is said to promote health and well-being by harmonizing the flow of energy, or “qi,” throughout the body. Qi Gong is a safe and gentle practice that can be done by people of all ages and fitness levels. It is a good way to …

Breathing, Hyperventilation, Carbon Dioxide and Panic

admin Anxiety, Basic Science, Psychobiology Leave a Comment

How does a panic attack relate to how we are breathing and the level of carbon dioxide and oxygen in our blood, and what is the fundamental flaw in brain programming that makes some of us so vulnerable to panic attacks? I was debriefing with a young woman who took too much of a new medication and ended up in …

Inflammation and Depression – Specific Symptom Cluster

admin Basic Science, Depression, Diagnosis, Major Depression, Physical Conditions and Health, Psychobiology Leave a Comment

A study of 15 population-based cohorts, totalling 56,351 individuals, suggests that there is a correlation between inflammation as measured by elevated  C-reactive protein (CRP) and interleukin-6 (IL-6) and a specific sub-group of symptoms of depression. The inflammation cluster consisted of four physical symptoms: changes in appetite, felt everything was an effort, loss of energy, sleep problems; and one cognitive symptom: little …

Family Risk of Bipolar 1 and 2 Disorders and Schizophrenia

Peter Forster Diagnosis, Psychobiology Leave a Comment

Interesting study out of Taiwan that uses their fairly comprehensive population based data set to look at the relative risk of having different disorders in a family where one parent either has bipolar one or bipolar two disorder. I found this study interesting in that it suggests that bipolar one has a higher genetic loading for any kind of bipolar …

Limbic and Prefrontal Connectivity and Treatment Selection for Depression

Peter Forster Basic Science, Best Practices, Major Depression, Psychobiology, Treatments of Depression

Boadie Dunlop, M.D., M.S., and Helen Mayberg, M.D., both of Emory University School of Medicine, and colleagues assessed resting-state functional connectivity between the subcallosal cingulate cortex (SCC) and three other brain regions—the dorsal midbrain, the ventrolateral prefrontal cortex and anterior insula, and the ventromedial prefrontal cortex—in 122 patients with depression. The patients were then randomized to 12 weeks of cognitive-behavioral …

Depression Resilience and Neural Connectivity

Peter Forster Basic Science, Major Depression, Psychobiology Leave a Comment

Much has been written about risk factors for depression but we know less about depression resilience factors. Why do some people at high risk develop depression, while others do not. A study conducted at Stanford by Adina S. Fischer, MD PhD, and colleagues, suggests that increased regulation of limbic areas (the parts of the brain that are most directly involved in …

Shared Gene Expression

Shared Gene Expression in Mental Disorders

Peter Forster Diagnosis, Psychobiology Leave a Comment

Four distinct psychiatric disorders – autism, schizophrenia, bipolar disorder and depression – have shared gene expression, according to research published online Feb. 8 in the journal Science. Researchers arrived at the study’s findings by analyzing RNA in 700 tissue samples from the brains of dead people who had autism, schizophrenia, bipolar disorder, major depression or alcohol abuse disorder, then comparing those samples …

State and Trait Brain Function in Depression

State and Trait Brain Function in Depression

Peter Forster Basic Science, Major Depression, Psychobiology Leave a Comment

Understanding the neurobiology of depression involves more than just knowing about serotonin, we need to know how state and trait brain function in depression is different from brain functioning in those who have never had a major depression. State and trait are key concepts in understanding psychiatric conditions: state refers to those alterations in functioning that occur when someone is …

Transmission of Distress Across Generations

Peter Forster Basic Science, Other Psychiatric Disorders, Psychobiology Leave a Comment

Transmission of Distress Across Generations Based on Epigenetic Changes Researchers looking at victims of severe trauma, such as concentration camp survivors, have long known that the effects of these events are transmitted in some fashion to the children and even the children’s children. The mechanism of this transmission has usually been assumed to be based on changes in parenting behavior …

Reduced Gene Expression in Reward Center is Linked to Depression

Peter Forster Basic Science, Major Depression, Psychobiology Leave a Comment

Researchers from the University of Maryland have conducted a series of experiments in mice and humans leading them to conclude that reduced gene expression in the reward center is linked to depression. Specifically, the researchers found that there was reduced expression of the Slc6a15 gene in the brains of people with major depression who committed suicide, and that expression of this …