Ketamine SQ Effective for Treatment-Resistant Depression: A Clinical Trial

adminDepression, Major Depression, Treatments of Depression Leave a Comment

A clinical trial conducted by researchers from UNSW Sydney has discovered that ketamine given as a subcutaneous shot effectively treats treatment-resistant depression. The findings, published in the journal the British Journal of Psychiatry, demonstrate that ketamine surpassed placebo in significantly reducing depressive symptoms. The trial involved 200 patients who had not responded to at least two other types of antidepressant …

Psychedelic Medicine Association

Psychedelic Medicine Association Member

adminAbout GPS, Other Psychiatric Disorders, Treatments of Depression Leave a Comment

Gateway Psychiatric just joined the Psychedelic Medicine Association. This membership is a continuation of our longstanding interest in alternative treatments for depression. I have been working with Bay Psychiatric Associates and Roberto Estrada for nearly five years providing ketamine infusion and now nasal esketamine to patients with treatment resistant depression. This followed attending the 2017 Ketamine Conference which was held …

Ketamine Short Term Treatment Strategies

Peter ForsterGPS, Major Depression, Treatments of Depression Leave a Comment

What are the best strategies for using ketamine to treat major depression in the short term? Although we know that ketamine (and, now, esketamine) can be helpful we really don’t know that much about what strategy works best. The most commonly used ketamine infusion protocol is adapted from studies using ketamine to treat chronic pain. An article in the March …

Gerard Sancora Esketamine is Effective

Intranasal Esketamine is Effective for Depression

Peter ForsterGPS, Major Depression, Treatments of Depression Leave a Comment

Intranasal esketamine is effective for treating severe depression and suicidality when added to comprehensive standard of care treatment in patients who were felt to be at imminent risk of suicide. 68 patients seen in an emergency department were randomized to receive esketamine or placebo as well as comprehensive treatment including inpatient care and antidepressant medications. Patients receiving esketamine had a …

Ketamine Reduces Suicidal Thoughts

Peter ForsterTreatments of Depression Leave a Comment

A single infusion of ketamine reduces suicidal thoughts in depressed patients in one day, with benefits lasting for up to one week, according to a meta-analysis reported in the American Journal of Psychiatry. Further, ketamine did not seem to be just treating depression, it seemed to have an effect on suicidal thinking that was greater than its effect on depression “This suggests that …

ketamine long term effects

Long Term Effects of Ketamine

Peter ForsterMajor Depression, Treatments of Depression Leave a Comment

One of my patients asked me what the long term effects of ketamine are. She was particularly interested in long-term adverse effects. The last time I did a review of the literature I noted that there seem to be very little information available. This is not surprising with the psychiatric literature since ketamine and its use for chronic depression are …

Ketamine for Depression – 2017

Peter ForsterBipolar Treatment, Major Depression, Treatments of Depression

I just got back from an inspiring conference in Berkeley on Ketamine for Depression. I am eager to implement some changes in how we work with people we refer or provide ketamine infusion for that may make the treatment more effective. The conference was organized by Alison McInnes, MD, MS, who is in charge of the Kaiser, San Francisco Ketamine Treatment Program, …

Ketamine Guidelines

Peter ForsterBest Practices, Treatments of Depression

Ketamine guidelines have recently been published by American Psychiatric Association Council of Research Task Force on Novel Biomarkers and Treatments. They highlight what we know and what we don’t know about this treatment. What We Know “Several studies now provide evidence of ketamine hydrochloride’s ability to produce rapid and robust antidepressant effects in patients with mood and anxiety disorders that were previously resistant …

Depression Therapeutics and Mechanisms

Peter ForsterMajor Depression, Psychobiology, Treatments of Depression

The September 15, 2016 edition of Biological Psychiatry is devoted to updates in the area of psychobiology that relate to depression and its treatment. In this blog post I will summarize some of those studies to give you a sense of what is going on in the field. Some of these studies may not be replicated in follow-up research, but some …